NEHODS Clonality Testing

NEHODS Clonality Testing

In partnership with the North East Haemato-Oncology Diagnostic Service (NEHODS) NewGene offers testing for T and B cell clonality.

Standard histopathological diagnosis of malignant lymphoma can be challenging. The use of a PCR based assay for the identification of clonal populations is a valuable tool as in principle B- and T-cell lymphomas are clonal diseases.

The PCR based test amplifies targeted regions of DNA in the conserved regions of antigen receptor genes that lie on either side of an area within the V-J region where programmed genetic rearrangements occur during maturation of all B and T lymphocytes. The antigen receptor genes that undergo rearrangement are the immunoglobulin heavy chain (IGH) & light chains genes (IGK) in B-cells, and the T cell receptor genes (TCR) in T-cells.

Contact us

NewGene Limited
Bioscience Building
International Centre for Life
Newcastle upon Tyne
NE1 4EP, UK

Tel: +44 (0)191 242 1923
Fax: +44 (0)191 241 8799
Email: info@newgene.org.uk

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Mon – Fri 08:30 to 17:00, closed Bank Holidays

An ISO 15189 accredited Medical Laboratory company

NewGene Limited | Company Number: 06735445

Technology Partners

Agilent Technologies

Agena Bioscience

Illumina

Sophia Genetics

Qiagen

Promega

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